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        <div id="content-top1">Page 11 - ScienceFocus (Issue 014)</div>
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    <pre style="white-space:pre-line"><code>Although there is a long way ahead for work       ??銝摨瑞?蝝啗?靘踹?賢?隞交??歹?敺葆靘?瑞?憯賢
on caloric restriction to be done on primates and      [2]? ??????頝???????????摮? 鈭?閫 撖???皜???銵?????頝?humans, the results from studies done on mice          鞊～摮?批??鞈芯?嚗ubcortical嚗???[3] ?偏???and monkeys show a promising possibility for           嚗audate嚗葉?鞈芷?蝛?隞亦雁????鞎祆?園???
caloric restriction being the key to longer life and   ?踝?motor function嚗?敺????摮貊?????improved health for all organisms, which offers clear
socioeconomic and health benefits for humanity.             ?舀嚗? ?嗅頝舫? ????憟質? ?芸頛僑?瑞???瘝喟
However as previously mentioned, the regime            嚗hesus monkey嚗??粹＊???∟楝???嗅?頛僑頛???conferred no benefits to younger animals, and          瘝???銝?瘝???撣?靘?憟質?? ??鈭?憿?????瘝????????????
clearer conclusions are yet to be drawn. Therefore,    隡?[4]嚗甇文隞交?瘀???∟楝????撠僑?犖?芸?
do only take the knowledge you have learnt here        ??嚗??唾??車擗?瘜?賭蒂銝????as food for thought!
                                                            甇文?嚗?蝛嗥??＊蝷粹??嗅頝舫????隞仿?雿銝? ??憭拚閬??車蝢?雿喲?銝剝?撌梁?銝?                                 ????撟湧翩?賊??曄?????∟楝???園?祕撽?
                                                       ?憿??拐葉?臭誑?潛嚗?擃??◢?芰??隞?????擗??訾縑憭批振?賜??蝭?園ㄡ憌?銝敺??蝬脖?嚗???                            ??摮??賊?皜? [5]?鈭????憸券?寥?迤?Ｙ?
?賭漲??唬???僑朣～批????閮??????亙                             雿嚗??嗅頝舫????摮銝?撟湧翩?賊??曄?嚗?憒?頝舫?撱箄降???之摰嗅??舀??賡?銝蝔桐蜓撘萄??瘥撱?                             敹?蝞∠???◢?芯漲銝?銝?頝舫??鈭虫撮銋???霅唳???銝?????嚗瘜????渡?擗??舀???                              ??亥???鈭?蝟倏??[3]??銝雲?????蝝?雿憭批??訾犖?賡虜銝??皜?瘥??亙頝舫???????荔??函?摮訾????????嗅頝舫?                                  ??券??琿??犖憿??∟楝???嗥??弦??銝璇?
????撠澈擃葆靘?蝟餃??末??靘??函??脯???                             ?瑞?頝航?韏堆?敺???摮?撌脤脰??祕撽?????
???菜???蝛嗡??賜?曉頝舫???辣?瑕ˊ?賜?雿??                             ?∟楝???嗆????箔誘????拙辣?瑕ˊ?賢??孵??亙熒?
??券??琿??犖憿??弦隞?券脰?銝哨??Ⅱ撖衣?隢?                              瘜???憿臬皜?蝷暹?銝?蝬?鞎???鈭粹?撣嗡??亙熒銝????嚗?敺???弦靘?嚗撮銋????箏?銝蝯???                            ????荔?憒??????∟楝???嗅?撟渲?
                                                       ??????銝?瘝???撣?靘?憟???????蝛?銝?????     擐?嚗?蝛嗥???蝣箸??粹??嗅頝舫????隞交???                          ??雿銝 ?? ???啁?蝯?嚗?甇歹?
??蝷?隞?雓?????皜?雿?瘞批? 憯?? 蝝???????蝺?蝎?擃???閫?蝝?          撣?雿瘨?隞乩??亥?敺??芯誑甇支?
????憌??抬???????蝟???蝺?蝎?擃??????箔? 鈭???瘣?????瘞?            ?箏??仿???銝??抬?Reactive Oxygen Species ??ROS嚗? ??摰???鞈迎?雿??箏?訾??函??舐?押?? ROS ?嗅??憯敦???瑽?靘? DNA?NA ??摰唾?嚗澈擃???銵啗???
??????蝛嗆??粹??嗅頝舫???????DNA ?拿
?芣撠蝯? 65% [1]嚗＊蝷粹??嗅頝舫??????拙辣??銵啗迨憭??弦銵函內??∟楝???隞交??Ｚ?頨恍?
?抒?銝鈭誨雓?嚗etabolic pathways嚗?敺?瘣颱?
鈭?銵啗??????※????瘨?蝝啗??芣?嚗飛銵?銝迂?箇敦??鈭⊥?蝔??抒敦?香鈭∴?嚗?隞文????誨
雓???metabolic stress嚗蔣?輻?蝝啗??脰??畾箝??綽?

References ????

[1] Kaneko T, Tahara S, Matsuo M. Retarding Effect of Dietary Restriction on the Accumulation of 8-Hydroxy-2??Deoxyguanosine in Organs of
    Fischer 344 Rats During Aging. Free Radic Biol Med. 1997;23(1):76-81.

[2] Kennedy MA, Rakoczy SG, Brown-Borg HM. Long-living Ames dwarf mouse hepatocytes readily undergo apoptosis. Exp Gerontol. 2003
    Sep;38(9):997-1008.

[3] Coleman RJ, Anderson RM, Johnson SC, et al. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science. 2009 Jul
    10;325(5937):201-4.

[4] Mattison JA, Coleman RJ, Beasley TM, et al. Caloric restriction improves health and survival of rhesus monkeys. Nat Commun. 2017 Jan
    17;8:14063.

[5] Omodei D, Fontana L. Calorie restriction and prevention of age-associated chronic disease. FEBS Lett. 2011 Jun 6;585(11):1537-42

                                                                                                                                                             9</code></pre>
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