Distinguished Seminar Series 香港分部杰出学者講座 219 Prof. Hendrik Luesch University of Florida, USA 美国佛罗里达大学 Intro: Prof. Luesch has established an integrated platform of total synthesis, pharmacological, genomic and proteomic profiling developed in his research to achieve compounds and to understand their activities on the cellular and molecular level. In this presentation, Prof. Luesch the general research flow for drug discovery. He took cancer, eye disease and lung disease as the examples, and talked about how they discovered drug candidates and evaluated the drug efficacy with different models as well as the elucidated the binding spot and targeting mechanism. Prof. Luesch’s talk demonstrates the big potential of marine natural products-based therapeutic drugs. 内容摘要：海洋是开发天然产物和治疗药 物的潜在资源。而将海洋天然产物发展为 治疗药物的必要条件是，有足够的药物让 科学家可以进行其作用机制方面的详细表 征。Luesch 教授正是建立了这样一个涵 盖全合成、药理学、基因组和蛋白质组学 分析的综合平台，从而有效获取化合物并 解析其在细胞和分子水平上的作用机制。 在此次演讲中，Luesch 教授介绍了药物 开发的一般研究流程，并以癌症、眼部 疾病和肺部疾病为例，讲述了其科研小组 是如何发现候选药物，用不同模型来评估 药物疗效，并阐明药物结合位点及靶向机 制。Luesch教授的演讲展示了海洋天然产 物作为治疗药物的巨大潜力。 Drug Discovery Inspired by Marine Cyanobacteria 海洋藍細菌启发下的药物開发 Distinguished Seminar Series 5 香港分部第五次杰出学者讲座 Date 日期 : 28 October 2021 (Thursday) 2021年10月28日 (星期四) Zoom Meeting 线上平台 ID : 994 8670 4389 Participants 参会者 : 70
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