37 Research Achievements 科研成果 • Develop an in-situ sensing technology, improving toxicity predictions for sediments; • Discover new coral and sea slug species in Hong Kong waters; • Unlock biogeographical secrets of deep-sea limpets, laying foundation for biodiversity conservation and environmental management; • Unlock genomic secrets of gutless deep-sea tubeworm, revealing the survival strategies of life in extreme deepsea ecosystems, and providing a basis for applications such asmanufacturing biological materials and inhibiting the reproduction of microorganisms; • Decode a deep-sea vent-endemic snail hologenome and unveils its living strategies in the extreme environment, bringing inspiration for the division of labor and cooperation between animals and microorganisms; • Reveal critical competition in a cell, shedding insights into intracellular rhage–bacteria interplay in deep-sea snail holobionts; • Develop an advanced genome mining-based biosynthetic gene family cloning and heterologous expression technology platform and big data analysis platform; • Develop multiple novel mechanisms that reveal bacterial resistance to peptide antibiotics; • Unlock the micro-molecular physiochemical mechanism of dental plaque formation, paving way for new preventive measures for tooth decay; • Identify the crystal structure of disease-related G-quadruplux for the first time, laying the foundation for the development of small molecule drugs. • 香港分部钱培元教授团队和邱建文教授 团队合作，解开无肠深海管虫的基因组 秘密，揭示深海极端生态系统中生命存 续策略；同时为制备生物材料及抑制微 生物繁殖等应用范畴提供理论基础； • 香港分部钱培元教授团队首次破译深海 热液神盾螺共生体基因组，揭秘其在地 球极端环境中的生存策略；有关研究结 果同时为科学界理解动物与微生物间的 分工合作提供重要启示； • 香港分部钱培元教授团队解析深海蜗牛 细胞内共生作用，揭密噬菌体与细菌间 的竞争关系； • 香港分部钱培元教授团队与李泳新教授 团队共同研究药物开发多学科平台，包 括基因组挖掘平台，生物合成基因族克 隆和异源表达技术平台，及大数据分析 平台； • 香港分部钱培元教授团队与李泳新教授 团队共同揭示细菌对多肽类抗生素耐药 新机理； • 香港分部钱培元教授团队与张文君教授 团队合作，首次破解人类口腔微生物小 分子代谢物促进牙菌膜形成的奥秘，为 预防蛀牙开辟新途径； • 香港分部钱培元教授团队与朱广教授团 队合作，首次解析神经遗传疾病基因序 列晶体结构，为小分子药物开发奠定基 础。
RkJQdWJsaXNoZXIy NDk5Njg=