Research Highlights 研究亮點 47 The Hong Kong Branch research team led by Prof. Wenxiong Wang used nano-scale secondary ion imaging mass spectrometry to detect the subcellular distributions of Mn in oocytes and sperm cells at different developmental stages. This is the first time that the enrichment of Mn was directly visualized in cortical granules. They found that the distribution and accumulation of Mn during oogenesis were closely associated with the formation and translocation of cortical granules. These results demonstrated great differences of the subcellular localization and accumulation capacity of Mn between oocytes and sperm cells in oysters, implying the sex differentiation in susceptibility of reproductive response to Mn stress. Their study also highlights the importance of gender difference in future biomonitoring and ecotoxicological studies of Mn in marine bivalves. The research findings have been published on Environmental Science & Technology. Reference: Environmental Science & Technology 2021, 55, 8223–8235 香港分部王文雄教授研究团队利用纳 米级二次离子成像质谱，对金属锰在牡 蛎生殖细胞中的亚细胞分布水平进行 检测，首次发现牡蛎卵子发育过程中锰 的分布和积累与皮质颗粒的形成和转移 密切相关。此项研究强调了性别差异对 锰的生物监测和生态毒理学研究中的重 要性。本研究成果发表于国际科学期刊 Environmental Science & Technology。 Discover the Subcellular Distribution of Manganese During Oyster Gametogenesis: Implying the Sex Differentiation in Susceptibility of Reproductive Response to Mn Stress 发現牡蠣配子发生過程中錳的亞細胞分布：暗示生殖反應 對錳脇迫的敏感性存在性別差異异 Prof. Wen-Xiong Wang 王文雄教授 City University of Hong Kong 香港城市大学 The enrichment of metal manganese in oyster germ cells 金属锰在牡蛎生殖细胞中的富集情况
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