Research Highlights 研究亮點 57 The HKB collaborative research team led by Professor PeiYuan Qian (Hong Kong University of Science and Technology), conducted metagenomic analysis of a deep-sea vent snail, with the aim to study the impact of prokaryotic virus (phage) on the deep-sea endosymbionts host animal living in hydrothermal vent. They discovered that the phage and host adopt different genes to develop anti-viral defense system and counter-host defense system, respectively. The balance of these genes allow the adoption endosymbiosis with chemosynthetic bacteria in deep-sea animals in hydrothermal vents. This study provides new insights into phage–bacteria interplay in intracellular environments of a deep-sea vent snail. The new findings have been published on the journal Microbiome. Reference: Environmental Microbiology Reports 2021, 13, 675-683 香港分部钱培元教授带领的合作科研团 队，为了解析热液喷口深海动物内共生 体原核病毒（噬菌体）对宿主的影响， 对深海蜗牛、及其共生体和噬菌体进行 了宏基因组分析。研究团队发现，噬菌 体和宿主采用不同的基因，分别发展出 抗病毒防御系统和反宿主防御系统。这 些基因的平衡表达使得热液喷口深海动 物中化能合成细菌与内共生共存。这项 研究为深海热液喷口动物内共生体相互 作用提供了新见解。这一发现已发表在 国际期刊Microbiome。 Reveal Critical Competition in a Cell: Insights into Intracellular Phage–bacteria Interplay in Deep-sea Snail Holobionts 揭密細胞中的競争關系：解析深海蝸牛全息生物中細胞內噬菌體 - 細菌相互作用 Prof. Pei-Yuan Qian 钱培元教授 The Hong Kong University of Science and Technology 香港科技大学 Visualisation of the four identified phage bins and endosymbiotic bacteria in a metagenomic map 宏基因组中显示四个已识别的噬菌体子序列集和内共生细菌
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