58 The HKB research Team led by Prof. Guang Zhu (The Hong Kong University of Science and Technology) identified the first crystal structure of G-quadruplux formed by twodiseases (amyotrophic lateral sclerosis and frontotemporal dementia) related GGGGCC sequence through a series of biophysical characterization. The d(G4C2)2 self-associates to form an eight-layer parallel tetrameric G-quadruplex. This unique high-resolution crystal structures are invaluable for designing/improving highly selective and stable small molecules for potentially ameliorating the pathology of ALS and FTD in the future. The new findings have been published on the journal Nucleic Acids Research. Reference: Nucleic Acids Research, 2021, 49, 5881–5890 香港科技大学朱广教授研究团队和钱 培元教授研究团队联手合作，通过一系 列生物物理学研究，首次鉴定出肌萎 缩侧索硬化症和额颞叶痴呆相关遗传 基因六核苷酸重复序列d ( G4C2 ) 2的晶 体结构。两个d ( G4C2 ) 2平行叠加形成 G-quadruplex二聚体，然后再折叠形成 四聚体。这种独特的高分辨率晶体结构 对我们开发小分子药物（比如从海洋生 物产生的天然化合物）来治疗神经退行 性疾病和额颞叶痴呆症提供了重要的结 构信息。此研究结果已发表在国际期刊 Nucleic Acids Research。 Identify the Crystal Structure of Disease-related G-quadruplux for the First Time, Laying the Foundation for the Development of Small Molecule Drugs 首次解析神经遺傳疾病基因序列晶體細構，為小分子药物開发 奠定基礎 Prof. Pei-Yuan Qian, Prof. Guang Zhu 钱培元教授 , 朱广教授 The Hong Kong University of Science and Technology 香港科技大学 Crystal structure of d(G4C2)2-Ba in the space group of C2221. d(G4C2)2-Ba 的晶体结构
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