Research Highlights 研究亮點 59 An inter-disciplinary team of researchers led by Prof. Qian Peiyuan, Chair Professor at the Hong Kong University of Science and Technology (HKUST)’s Department of Ocean ScienceandDivisionof LifeSciencehasunraveledhowanovel microbial small molecule released by Streptococcus mutans (S. mutans) – a bacterium commonly found in the human oral cavity – is connected to dental caries development using a synthetic biology approach, offering new insights to the health impact of the human oral microbiota and facilitating future research on the prevention of tooth decay. The research findings were recently published in the prestigious scientific journal Nature Chemical Biology and reported by Nature as one of the research highlights. Prof. Qian, also David von Hansemann Professor of Science at HKUST, said, “Our findings provide the first example of a microbial secondary metabolite promoting biofilm formation via a physicochemical approach, highlighting the significance of secondary metabolism in mediating critical processes related to the development of dental caries.” Refer to HKUST news/参考科大新闻: https://science.hkust.edu.hk/news/hkust-researchers-unlock-micro-molecular-physiochemical-mechanism-dental-plaque-formation Reference: Nature Chemical Biology 2021, 17, 576-584 香港分部钱培元教授研究团队与张文君 教授研究团队，合作揭示人类口腔变形 链球菌释放出的新型微生物小分子与蛀 牙的形成有关。此突破性成果为我们认 识人类口腔微生物群对健康的影响提供 了新的科学证据，推动了未来预防蛀牙 的研究。该研究成果已发表在权威前沿 科学杂志Nature Chemical Biology，并 成为Nature的亮点报道。 钱教授表示：“我们首次发现了微生物次 生代谢产物是通过理化机制促进生物膜 形成，突出了次生代谢产物在形成蛀牙 的关键过程中发挥的作用及重要性” Unlock the Micro-Molecular Physiochemical Mechanism of Dental Plaque Formation: Paving Way for New Preventive Measures for Tooth Decay 破解人类口腔微生物小分子促進牙菌膜形成的奥秘：為預防蛀牙 開辟新途徑 Prof. Pei-Yuan Qian 钱培元教授 The Hong Kong University of Science and Technology 香港科技大学 Prof. Wenjun Zhang 张文君教授 University of California, Berkeley 加州大学伯克利分校
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