Short Biography of Project Coordinator Professor Zhiwei Chen is an expert in the field of HIV/AIDS and emerging infectious diseases. He is an inventor/co-inventor of two AIDS and two COVID-19 vaccines, which have been developed from the laboratory to human phase I trials in the Mainland and Hong Kong. His invention of PD1-based DNA vaccines and bi-specific antibodies against HIV/AIDS serves the core of this project. Prof Chen has obtained many grants, including TRS, the General Research Fund, the Collaborative Research Fund, and Health and Medical Research Fund in Hong Kong, as well as international fundings from National Institutes of Health and the Bill & Melinda Gates Foundation. With his coordination, the research team generates consistently high-impact research outputs and promotes the technology transfer of the “made in Hong Kong” immunotherapeutic products for clinical development. Project Summary To determine correlates of PD1-based vaccine and BiIA-SG- induced protection in SHIVSF162P3CN-infected rhesus macaques. To determine immunogenicity and efficacy of GLP-grade human PD1-based vaccine and BiIA-SG in animal models in support of Investigational new drug (IND) application. To investigate the possible functional cure of HIV-1 infection in patients by PD1-based vaccine and BiIA-SG immunotherapies. 項目概要 研究 PD-1 增強型 DNA 疫苗和雙特異性抗體在 SHIV SF162P3CN 感染的恒河猴中誘導的保護效力。 研究 GLP 級別生產的人 PD-1 增強型 DNA 疫苗和雙特異性抗體 在動物模型中的免疫原性和功效，以支持新藥臨床試驗 ( IND) 申請 。 探討 PD-1 增強型 DNA 疫苗和雙特異性抗體免疫療法對 HIV-1 感染者功能性治癒的可能性。 項目統籌人簡介 陳志偉教授是愛滋病和新興傳染病領域的專家。他是兩種愛滋 病疫苗和兩種新冠肺炎疫苗的發明者 / 共同發明者。目前，這 些疫苗均已在內地和香港從實驗室研發階段進階至 I 期臨床試 驗階段。陳教授團隊研發的 PD-1 增強型 DNA 疫苗和雙特異 性抗體是此項目的核心關鍵。陳教授獲得了多項研究基金的資 助，包括香港的主題研究計劃、優配研究金、協作研究金和 醫 療衞生研究金項目，以及來自美國國立衞生研究院和比爾及梅 琳達蓋茲基金會的海外資助。在他的統籌下，研究團隊不僅持 續產出高影響力的研究成果，並促進「香港製造」免疫療法候 選藥物的技術轉移以應用於臨床。 Professor Kwok-Yung Yuen visiting ICVAX clinical trial onsite 袁國勇教授現場考察指導ICVAX臨床研究 The research team working in Laboratory 在實驗室工作的研究團隊 8 Potentiating Host Immunity for HIV-1 Functional Cure 增強宿主免疫實現HIV-1功能性治癒 T11-706/18-N Project Coordinator Professor Zhiwei CHEN The University of Hong Kong 項目統籌人 陳志偉教授 香港大學 Participating Institution The Chinese University of Hong Kong 參與院校 香港中文大學 THEME 主題 1 | Understanding Diseases and Disease Prevention 剖析疾病及疾病預防
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