Photo of Project Team and Scientific Advisory Board 研究團隊與科學諮詢委員會留影 Research Impact Our research program has produced important and high-impact scientific findings on individual and population immunity to influenza, and made essential contributions to evidence-based policy making during the COVID-19 pandemic. Our multidisciplinary influenza research group is recognised as world-leading, and demonstrated our value to Hong Kong SAR, greater China, and the world during the COVID-19 pandemic where we published a large number of top-tier publications, advised local, national and international health agencies, and frequently communicated our knowledge and recommendations to the public via traditional and social media. 研究影響 我們的研究計劃在個人和群體的流感免疫力方面取得了重要且 具有很高影響力的科學成果，並在 2019 冠狀病毒病大流行期 間為實證政策作出了重要貢獻。我們的跨學科流感研究團隊獲 認可為全球領先，在 2019 冠狀病毒病大流行期間，我們發表 了大量頂尖論文，為本地、國家和國際衞生機構提供意見，並 通過傳統和社交媒體頻繁地向公眾傳播知識和提供建議，向香 港特別行政區、大中華地區及世界展示了我們的價值。 Abstract Influenza is a major threat to global public health. Seasonal influenza viruses cause annual epidemics with significant morbidity and mortality but existing vaccines are not optimal. Our own studies have shown that hemagglutination inhibition antibody titers, which are the current correlate of protection against influenza, only explain around 57% of the protective effect of conventional inactivated vaccines. These antibodies are even less correlated with the protection provided by live attenuated influenza vaccines or new vaccines currently in development. Therefore, key knowledge gaps addressed in this project: (a) what are the immune correlates of protection against influenza infection or severe disease; (b) which of these are induced temporarily or permanently by prior natural infection or different types of vaccination; (c) what are the factors which contribute to increased susceptibility of populations to influenza epidemics; (d) how should we best deploy new and existing influenza vaccines to reduce the impact of influenza epidemics and pandemics; and (e) what are other immunological mechanisms relevant to the development and evaluation of new influenza vaccines. The relevance of these and other previously undefined mechanisms for protection against infection and disease in humans is the major knowledge gap. 項目簡介 流行性感冒嚴重威脅全球公共衞生。季節性流感病毒能導致每 年流感大流行及引發顯著的發病和死亡率，但現有的流感疫苗 並非最佳的抗病疫苗。我們過往的研究發現，血球凝集抑制抗 體滴度（目前已知具有防護流感感染的抗體滴度）僅能解釋常 規滅活疫苗約 57％的保護作用。這些抗體較目前正在研發的減 活或新型流感疫苗所提供的保護性更低。 因此，此項目關鍵的知識差距為：（一）什麼是預防感染或嚴 重疾病的免疫相關保護因子 ;（二）哪些免疫相關保護因子屬 暫時或永久性，並源自先前的自然感染或不同類型的疫苗接 種 ;（三）什麼因素導致人類群體對於流感有更高的易感性 ; （四）如何有效地配給嶄新和現有的流感疫苗，以減輕流感大 流行和流行病的影響 ;（五）了解免疫機制以開發和評估下一 代新型流感疫苗。此研究項目有助了解上述領域和其他未釐定 的人類病毒感染之後宿主的免疫機制。 11
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