12 Short Biography of Project Coordinator Nancy Kwan Man, MBBS, MS, PhD, is the Chair Professor of Transplant Oncology and Immunology in Department of Surgery, The University of Hong Kong. She is the Director of Clinical and Translational Research Laboratory, Director of Liver Transplantation and Liver Cancer Research, and Director of the Laboratory for Organ Transplantation and Regeneration. She is also the President of Hong Kong Society for Immunology, and President of Hong Kong Scientist Association. Dedicated to enhancing the outcomes of liver transplantation through reducing graft injury and cancer recurrence, Nancy leads research endeavours encompassing basic, clinical, and translational studies resulting in major advances on transplant oncology and immunology in the world. As the top 2% Scientists Worldwide on Stanford List, Nancy has published more than 210 papers in leading international journals with 17000 citations (H index 74). She and her team received numerous international awards including Basic Science Established Investigator Award and Rising Star Awards from International Liver Transplantation Society (ILTS), and Mentor/Mentee Awards from The Transplantation Society (TTS). Project Summary To understand the role of regional specialization of immune system in tumor recurrence and hepatitis B after liver transplantation by the approach of systems biology integrated with a series of clinical, basic and translational studies. The new concept of immunotherapies will be developed by educating the intragraft immune micro-environment to prevent tumor recurrence after liver transplantation and to achieve the long-term survival. To establish a new modeling system that integrates high-throughput sequencing data and biology/immunology parameters not only for predicting disease recurrence and prognoses, but also for therapeutic guidance. To explore the mechanism of marginal liver graft injury and to establish novel therapeutics to overcome graft injury by using bioengineered cells targeted for regional tissue repair and functional regeneration. 項目概要 通過一系列基礎、臨床與轉化研究來揭示肝移植後原發病復 發的機制，尋找有效的生物標記物，並開發新的免疫治療方 案，從而減少移植後乙肝和肝癌的復發，提高肝移植病人的長 期生存率。 整合高通量基因測序及生化和免疫數據，建立一個嶄新的智 能模型，不僅能用於腫瘤復發的預測，亦對治療策略的選擇 具有重要的指導意義。 探索促進肝組織修復和再生的新策略，為進一步擴大供體來源 和避免移植肝損傷及失功能提供理論依據和新的治療方案。 項目統籌人簡介 萬鈞教授現任香港大學外科學系講座教授（移植腫瘤學及免疫 學 )，香港大學外科學系臨床與轉化實驗室主任，器官移植與 再生實驗室主任，肝移植與肝癌實驗室主任。主要從事肝臟移 植損傷，肝癌及其肝移植後腫瘤復發的臨床，轉化和基礎研 究，提出移植腫瘤學與免疫學的新概念。發現並闡明小體積移 植肝損傷及肝移植後肝癌復發的新機轉。研究成果處於相關領 域的國際領先水平，並在多家國際知名期刊上發表了超過 210 篇論文，其中包括：Journal of Hepatology, Gastroenterology, Annals of Surgery, Transplantation, Liver Transplantation, Clinical Cancer Research and Cancer Research, New England Journal of Medicine, Nature Medicine 等。引 用 次 數 超 過 17000 次 (H index 74)。2013-2019 年起連續七年被評為港大 最高（1%）引用率學者，她是史丹福大學 2023 全球前 2% 頂 尖科學家。近 16 年來萬鈞教授帶領的研究團隊在肝臟移植， 肝癌和肝炎的研究領域獲得超過 65 項國際大獎。 Fighting Disease Recurrence and Promoting Tissue Repair after Liver Transplantation: Translating Basic Discoveries to Clinical Excellence 肝移植後原發病復發和組織修復的科研攻堅： 從轉化基礎研究到優化臨床決策 T12-703/19-R Project Coordinator Professor Nancy Kwan MAN The University of Hong Kong 項目統籌人 萬鈞教授 香港大學 Participating Institution The Chinese University of Hong Kong 參與院校 香港中文大學 THEME 主題 1 | Understanding Diseases and Disease Prevention 剖析疾病及疾病預防
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