UROP Proceeding 2023-24

Summary of Research Activities: During my research internship in Prof. Voskoboynik’s lab, I contributed to the establishment of a work ow that identi es adaptive immunity gene candidates based on sample-speci c variation—a key feature of adaptive immunity. Previous efforts focused on constructing a gene model, highlighting regions with high sequence similarity to known adaptive immunity genes. Unfortunately, these efforts did not yield many signi cant results. My contributions involved a different approach, which showed promise in identifying potential adaptive immunity genes in Botryllus. This experience has been invaluable in deepening my understanding of immunology and bioinformatics, as well as providing me with hands-on experience in cutting-edge research. One of the most inspiring aspects of my internship was the opportunity to work alongside the talented researchers at Hopkins Marine Station. I had the privilege of interacting with creative engineers who brought ideas to life, such as physically visualizing DNA sequencing using custom LEGOs and employing 3D printing to turn memories into tangible objects. I also met researchers whose working hypotheses are exciting in themselves. Being surrounded by experts who were so skilled in their respective elds was both humbling and motivating. It brought me closer to the forefront of scienti c discovery, making the process of extending the boundaries of human knowledge feel tangible and within reach. YU Jiamu Major : BCB Supervised by : Prof. WU Angela Ruohao / LIFS Activity : Undergraduate Visiting Research Interns Venue : Stanford University, USA Duration : June 17 to August 31, 2024 xv

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