School of Science Department of Chemistry 7 Evolutionary Analysis of Hemagglutinin and Neuraminidase Mutations in Influenza Virus Supervisor: SU Haibin / CHEM Student: CUI Yikuan / CHEM Course: UROP 1000, Summer As a member of Professor Su's research group focused on the "Evolutionary Analysis of Hemagglutinin and Neuraminidase Mutations in Influenza Virus," I have undertaken several tasks as part of this project. This has included reviewing the current scientific literature, modeling molecular structures using PyMOL, conducting multiple sequences alignment (MSA) to find mutant regions and sites, and collecting and analyzing relevant data. In this essay, I will summarize the key insights gained from the literature review, discuss our further findings about molecular interactions using PyMOL and MSA, and explain the progress our group has made toward influenza treatment options in the computational chemistry field. Evolutionary Analysis of Hemagglutinin and Neuraminidase Mutations in Influenza Virus Supervisor: SU Haibin / CHEM Student: GUI Weishi / BCB XIONG Yule / BIBU Course: UROP 1000, Summer UROP 1100, Summer Influenza A virus (IAV) is a highly pathogenic virus with a single-stranded, segmented RNA genome encased in a lipid envelope. Hemagglutinin (HA) and neuraminidase (NA) are key viral proteins that play essential roles in the infection process. This study focuses on the mutational impact and drug resistance patterns of Influenza A virus, particularly in relation to the neuraminidase enzyme and neuraminidase inhibitors (NAIs). Through deep mutational scanning and structural analysis, the research delves into the molecular mechanisms of drug resistance in H5N1 strains. Additionally, the study explores the local fitness landscape of HA antigenic site B across different human virus strains, revealing how the virus adapts and explores new antigenic regions despite functional constraints. Evolutionary Analysis of Hemagglutinin and Neuraminidase Mutations in Influenza Virus Supervisor: SU Haibin / CHEM Student: XIE Yunfei / BIBU Course: UROP 1000, Summer Through studying in a group with the aim of creating a comprehensive network of knowledge about influenza viruses, I learned about how these specific viruses threaten humans and how they transition from animals. Additionally, we focused on data related to mutations and recombination and the evolutionary progress of certain influenza viruses. By reading related articles, we gained different insights into how to further refine the model we were using and clarified the type of data or sequences we needed. By combining the knowledge gained from articles and the results or conclusions reached through data analysis, we gained a clearer view of the field of influenza.
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