School of Science Division of Life Science 18 Chinese Herbal Medicine for General Health Supervisor: LIANG Chun / LIFS Student: CHEN Yifan / BIOT Course: UROP 1100, Fall The purpose of this experiment was to study the effect and selectivity of Chemical drug CM2 when acting on normal cells and cancer cells under different conditions. Through colony formation assay, drug treatment and recovery assay and other experimental methods, it was concluded that high concentrations of CM2(100ng/ml) has significant killing ability for all cells and a certain concentration of CM2(30ng/ml) showed some differences in its ability to kill different cells and the same type of cell in their different phase in cell cycle; inhibition effect of CM2 on Palbo sensitive cells was weakened when CM2 and Palbo were applied together. Chinese Herbal Medicine for General Health Supervisor: LIANG Chun / LIFS Student: NG Cheuk Yan Gloria / BCB Course: UROP 3200, Fall The requirement for accurate structure predictions of novel nucleic acid structures has become everincreasingly important as the discovery of more diverse nucleic acid families have become important in understanding key biological interactions besides the storage of genetic information, and the feasibility of developing de novo nucleic acid structures like aptamers and nanostructures to serve as drug molecules or carriers, biosensors, or nanofabrication applications. While existing nucleic acid structure predictors that use an attention-based architecture to decipher features of nucleic acid tertiary structures have recently become popular, their large computational requirements, long training time, and narrow scope in terms of what species of nucleic acids the model can generate have all limited their widespread usage in structural biology. This work demonstrates and evaluates universal approach to nucleic acid structure prediction that focuses on modelling trends based on the chemical and physical features of both DNA and RNA from a much more streamlined attention mechanism that uses lower computational power. Chinese Herbal Medicine for General Health Supervisor: LIANG Chun / LIFS Student: TSANG Chun Kit / BCB Course: UROP 3100, Fall UROP 4100, Spring Obesity has become an increasingly prevalent issue worldwide and adequate solutions apart from physical interventions needs to be considered to increase the effectiveness of weight management across diverse groups of individuals. The effects of Ercehn decoction in lipid metabolism and adipocyte browning is evaluated using 3T3-L1 as the model. Results show down-regulatory action for SREBP1 and FAS, as well as up-regulation of PGC1 and UCP1 along with increased activation of AMPK with ECD treatment. This suggests that ECD could induce adipose tissue browning and inhibits lipogenesis, which contributes to the overall regulatory effects for adipose tissue.
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