School of Science Division of Life Science 31 Mechanistic Investigation of Mitochondrial Quality Control Supervisor: WANG Lan / LIFS Student: YU Chun Ip William / BIBU Course: UROP 1100, Spring ATPase associated with diverse cellular activities domain-containing protein 3 (ATAD3) is a mitochondrial protein that plays a vital role in regulating mitochondria DNA, structure, cristae morphology, and hence their function. In recent years, there have been studies on their function in cells and their substrate. However, in general, the public still has a minimal understanding of its primary role and the exact location where ATAD3 resides in the intermembrane space is still yet to be found. This progress report tried to study the effect of ATAD3 in mitochondria by creating si-ATAD3 mouse myoblast cells and investigating the effects of gene silencing on cells’ differentiation, then protein level through western blot, and eventually mRNA and gDNA level through quantitative PCR. Due to time limitations, experiments like the western blot of OXPHOS complex expression level and qPCR of mitochondrial mRNA and gDNA were carried out by mentor, Wang Jin, and here we summarize and discuss the results. Carbon 6x Minus Through Increase Production of DMSP Supervisor: WONG Joseph Tin Yum / LIFS Student: LEE Sum Yeung Sunny / BCB Course: UROP 1000, Summer This literature review examines the interplay between redox potential, sulphur content regulation, and cellular processes, focusing on their potential impact on dimethyl-sulfoniopropionate (DMSP) levels in marine environments. Discussions highlight the regulatory mechanisms of redox potential and sulphur content in cellular events, emphasizing their relationship with DMSP. The review indicates the importance of understanding how cells balance antioxidant functions and cellular processes in response to environmental cues. The intricate connections between redox potential, sulphur content, and DMSP levels offer valuable insights into cellular physiology and environmental dynamics, shaping our understanding of redox signalling pathways and their role in maintaining cellular homeostasis. Dinoflagellate Bioluminescences Are Not Only for the Tourists Supervisor: WONG Joseph Tin Yum / LIFS Student: LI Tsz Long / BISC Course: UROP 1100, Summer Various mechanisms and phenotypes evolved to give organisms an edge in survival; the eye-catching phenomenon of bioluminescence is one of the representatives. Most lifeforms in the marine environment could exploit light emission, for instance, predator defense, as a cloaking device or lure for prey (Cusick & Widder, 2020). While dinoflagellates are renowned for their potential catastrophe in forming harmful algal blooms and light displays at night in eco-tourisms, the underlying ecological and functional significance for the latter remains uncertain. This report thus aims to clarify the basis of the bioluminescence system in dinoflagellates as the stepping stone to untangle its intricacy.
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