School of Engineering Department of Chemical and Biological Engineering 88 Developing Stable Solution Inks for Perovskite Solar Cells Supervisor: ZHOU Yuanyuan / CBE Student: LEE Seungtae / CENG Course: UROP 1000, Summer Perovskite solar cells (PSCs) show promise as next-generation photovoltaic technology, with the hole transport layer (HTL) crucial for efficient hole extraction. This study investigates the impact of different HTL compositions on PSC performance, comparing devices with SAM1, SAM1 + NiOx, and SAM2 + NiOx as HTLs. Perovskite solar cells were fabricated and characterized using current density-voltage measurements. The SAM1 + NiOx HTL configuration achieved the highest average power conversion efficiency (PCE) of 18.7%, compared to 16.6% for SAM1 and 17.3% for SAM2 + NiOx. These results suggest that combining selfassembled monolayers (SAMs) with nickel oxide (NiOx) can improve PSC efficiency by enhancing charge extraction and transport. Further optimization of HTL composition and interface engineering may lead to even higher device efficiencies. Encoding Immune Evasion to Adeno-Associated Virus Vectors for Gene Therapy Supervisor: ZHU Bonnie Danqing / CBE Student: LIU Ganye / BIEN Course: UROP 1100, Spring This report explores the optimization of adeno-associated virus (AAV) vectors for gene therapy by enhancing their resistance to neutralizing antibodies (NAbs). We aim to employ a computational technique to identify epitopes on AAV complexes, instead of its monomer. Using computer algorithms, we reconstruct protein complexes and analyze the influence of pH on epitope charge. Our findings indicate that many epitopes demonstrate conserved patterns across AAV variants, suggesting that certain sequences are critical for maintaining the structural integrity of the virus. This research highlights the importance of understanding epitope characteristics for optimizing immune evasion strategies in AAV designs, ultimately contributing to more effective gene therapy applications.
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