School of Science Department of Chemistry 8 Design, Synthesis, and Applications of New Metal-Organic Frameworks Supervisor: QUAN Yangjian / CHEM Student: NGUYEN Tien Thinh / CHEM Course: UROP 1000, Summer Alkynes serve as pivotal building blocks in organic synthesis, with alkyne hydroboration emerging as a powerful strategy to access versatile organoboron compounds. Current research has primarily focused on three-coordinate boron species, leaving the potential of four-coordinate boron species largely unexplored. Herein, we summarize recent applications of four-coordinated boron species in the synthesis of diverse boron-containing frameworks via two distinct mechanistic routes—involving either the borenium cation or the boryl radical. By expanding the scope of hydroboration chemistry, these methods provide precise control over reactivity and selectivity, aiming to bridge existing gaps in boron chemistry while opening new avenues for the development of advanced functional materials and bioactive molecules. New Methodologies for Organoborane Synthesis Supervisor: QUAN Yangjian / CHEM Student: GAO Bin / CHEM Course: UROP 3200, Fall In the previous project (UROP 2100), we developed a pioneering boron cation-catalyzed remote borylation that is notable for being metal-free and exhibiting unique functional group tolerance. To showcase the synthetic potential of this reaction, we applied it to silyl alkenes rather than simple alkenes, successfully synthesizing silyl-remote-boryl compounds. Given the versatile synthetic potential of these two groups, further functionalization will depend on the differing properties of the silyl and boryl groups in the product, ultimately leading to the formation of difunctionalized alkanes.
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