School of Science Department of Chemistry 11 Evolutionary Analysis of Hemagglutinin and Neuraminidase Mutations in Influenza Virus Supervisor: SU Haibin / CHEM Student: XIE Yunfei / BIBU Course: UROP 1100, Spring UROP 2100, Summer In the influenza virus, mutations within the virus genome may trigger different influences on the viral infectivity, stability and host adaptation. Mutations expressed on the virus glycoprotein can change the binding power of the influenza virus to its host. In some of the studies, mutations on HA were learnt by scientists, which attenuate the virus’s infection process. This report mainly focuses on the review of how mutations on the Influenza virus influence the membrane fusion process and the methodologies assessing the affinity. Methodology Development for Time Series Data Supervisor: SU Haibin / CHEM Student: SU Yilin Hanako / MATH-AM Course: UROP 2100, Fall UROP 3200, Summer Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a huge threat to our global community since 2019. Although the coronavirus disease (COVID-19) caused by SARS-CoV-2 is no longer treated as a public health emergency, SARS-CoV- 2 continues to evolve into new variants. Since the virus continuously mutates itself, it is possible that it can evolve into a virus with increased transmissibility and higher mortality rates. This ongoing evolution signifies the need for careful monitoring and prediction of viral behavior. To address this challenge, this project aims to develop a mathematical model that describes and predicts the evolutionary behavior of SARS-CoV-2. The Impact of Spike Mutations on SARS-CoV-2 Neutralization Supervisor: SU Haibin / CHEM Student: CHOW Baylon Philip / CHEM-IRE Course: UROP 1100, Summer Microalgal fuels offer a promising alternative to conventional biofuels, addressing key limitations of current feedstocks. Studying their metabolism could enable bioengineering strategies to optimize biofuel precursor biosynthesis. Chorella is a prime species for use in biofuel production due to their high lipid productivity, and nitrogen starvation is of particular interest as it has been shown to increase lipid production in microalgae. In this study, I summarize to understand the effects of nitrogen starvation of Chlorella strains.
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