References 參考資料： [1] Chang, A. Y., & Purt, B. (2023, June 5). Biochemistry, Tear Film. StatPearls. StatPearls Publishing. https://www.ncbi. nlm.nih.gov/books/NBK572136/ [2] Vera-Montecinos, A., Pardo, C. C., Hernández, M., Saldivia, P., Nourdin, G., Elizondo-Vega, R., Sánchez, E., Amulef, S., Koch, E., Vargas, C., & Oyarce, K. (2025). High throughput tear proteomics with data independent acquisition enables biomarker discovery in allergic conditions. Scientific reports, 15(1), 31181. https://doi.org/10.1038/s41598-025-17105-y [3] Collier, L. (2014, February). Why we cry. Monitor on Psychology, 45(2), 47. https://www.apa.org/ monitor/2014/02/cry [4] Dartt, D. A. (2009). Neural regulation of lacrimal gland secretory processes: Relevance in dry eye diseases. Progress in Retinal and Eye Research, 28(3), 155–177. https://doi.org/10.1016/j.preteyeres.2009.04.003 [5] Meng, I. D., & Kurose, M. (2013). The role of corneal afferent neurons in regulating tears under normal and dry eye conditions. Experimental Eye Research, 117, 79–87. https://doi.org/10.1016/j.exer.2013.08.011 [6] Pagan-Duran, B. (2022, February 9). Lubricating Eye Drops for Dry Eyes. EyeSmart, American Academy of Ophthalmology. https://www.aao.org/eye-health/ treatments/lubricating-eye-drops [7] Semp, D. A., Beeson, D., Sheppard, A. L., Dutta, D., & Wolffsohn, J. S. (2023). Artificial Tears: A Systematic Review. Clinical Optometry, 15, 9–27. https://doi. org/10.2147/OPTO.S350185 [8] Fong, P. Y., Shih, K. C., Lam, P. Y., Chan, T. C. Y., Jhanji, V., & Tong, L. (2019). Role of tear film biomarkers in the diagnosis and management of dry eye disease. Taiwan Journal of Ophthalmology, 9(3), 150–159. https://doi. org/10.4103/tjo.tjo_56_19 [9] Shang, X., Zhang, Y., Luo, S., Liu, M., Li, H., Fang, X., Xie, Z., Xiao, X., Yang, Z., Lin, Y., & Wu, H. (2025). Tear IgE point-of-care testing for differentiating type I and type IV allergic conjunctivitis. Frontiers in Medicine, 12. https://doi.org/10.3389/fmed.2025.1577656 [10] Gijs, M., Ramakers, I. H. G. B., Visser, P. J., Verhey, F. R. J., van de Waarenburg, M. P. H., Schalkwijk, C. G., Nuijts, R. M. M. A., & Webers, C. A. B. (2021). Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration. Scientific Reports, 11(1), 22675. https://doi.org/10.1038/s41598-021-01993-x [11] Kalló, G., Emri, M., Varga, Z., Ujhelyi, B., Tőzsér, J., Csutak, A., & Csősz, É. (2016). Changes in the Chemical Barrier Composition of Tears in Alzheimer's Disease Reveal Potential Tear Diagnostic Biomarkers. PLoS one, 11(6), e0158000. https://doi.org/10.1371/journal.pone.0158000 [12] Park, W., Seo, H., Kim, J., Hong, Y., Song, H., Joo, B. J., Kim, S., Kim, E., Yae, C., Kim, J., Jin, J., Kim, J., Lee, Y., Kim, J., Kim, H. K., & Park, J. (2024). In-depth correlation analysis between tear glucose and blood glucose using a wireless smart contact lens. Nature Communications, 15(1), 2828. https://doi.org/10.1038/ s41467-024-47123-9 [13] Fisher, R. (n.d.). The Topography of Tears. https://roselynnfisher.com/tears.html 11 多發性硬化症在淚液中可被觀察到含量上升的生物標記 [10]；科學家也正努力尋找阿茲海默症的可靠生物標記。 如果淚液篩檢測試最終能成功開發並推出市場，我們將 能在社區進行大規模篩檢，始終早期診斷和治療能改善 患者及照顧者的生活質素 [11]。 在使用淚液的醫療裝置方面，最近一項研究提出糖尿 病患者透過智能隱形眼鏡監測淚液葡萄糖水平的可能性 [12]。以往以淚液代替血液量度葡萄糖水平的挑戰在於 淚液採集方法，使用傳統的單次淚液採集方法（如濾紙 條和毛細管條等）總會刺激眼睛分泌反射眼淚，干擾量 度結果。透過在軟式隱形眼鏡中嵌入天線、葡萄糖感測 器和 NFC 晶片，研究團隊能夠持續監測基礎眼淚中的葡 萄糖水平，並能實時將數據傳輸至行動裝置。 儘管淚液可能含有一系列能揭示我們健康狀況的生 物標記，但在相關技術進入臨床應用之前仍有很長的路 要走。隨著科學家更努力去尋找生物標記和研發更先進 的醫療裝置，淚液有一天將能成為反映我們健康狀況的 有力指標。 眼淚的形狀 其中一種研究眼淚的藝術方法是把其放在顯 微鏡下觀看，鑑賞風乾後的晶體，或壓在蓋玻片 下的淚液 [13]。攝影師Rose-Lynn Fisher因 此展開了名為「眼淚拓撲學」的計劃，以顯微照 片記錄她和朋友在不同場合下流過的眼淚。 更多資訊：
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